| Date | Home | Away | Result |
|---|---|---|---|
| 15/05/10 17:00 | Athletic Bilbao | Deportivo La Coruna | 2-0 |
| 15/05/10 19:00 | Atletico Madrid | FC Getafe | 0-3 |
| 15/05/10 19:00 | Real Saragossa | FC Villarreal | 3-3 |
| 15/05/10 21:00 | UD Almeria | FC Sevilla | 2-3 |
| 15/05/10 21:00 | RCD Mallorca | Espanyol Barcelona | 2-0 |
| 16/05/10 18:00 | Racing Santander | Sporting Gijon | 2-0 |
| 16/05/10 18:00 | FC Barcelona | Real Valladolid | 4-0 |
| 16/05/10 18:00 | FC Valencia | CD Teneriffa | 1-0 |
| 16/05/10 18:00 | CA Osasuna | Deportivo Xerez | 1-1 |
| 16/05/10 18:00 | FC Malaga | Real Madrid | 1-1 |