| Date | Home | Away | Result |
|---|---|---|---|
| 20/05/22 20:00 | Real Madrid | Real Betis Sevilla | 0-0 |
| 20/05/22 20:00 | Rayo Vallecano | UD Levante | 2-4 |
| 21/05/22 16:30 | FC Valencia | Celta Vigo | 2-0 |
| 22/05/22 16:30 | FC Elche | FC Getafe | 3-1 |
| 22/05/22 19:00 | Deportivo Alaves | FC Cadiz | 0-1 |
| 22/05/22 19:00 | FC Granada | Espanyol Barcelona | 0-0 |
| 22/05/22 19:00 | CA Osasuna | RCD Mallorca | 0-2 |
| 22/05/22 21:00 | FC Barcelona | FC Villarreal | 0-2 |
| 22/05/22 21:00 | Real Sociedad | Atletico Madrid | 1-2 |
| 22/05/22 21:00 | FC Sevilla | Athletic Bilbao | 1-0 |