| Date | Home | Away | Result |
|---|---|---|---|
| 21/05/21 20:00 | UD Levante | FC Cadiz | 2-2 |
| 22/05/21 17:00 | Real Valladolid | Atletico Madrid | 1-2 |
| 22/05/21 17:00 | Real Madrid | FC Villarreal | 2-1 |
| 22/05/21 17:00 | SD Huesca | FC Valencia | 0-0 |
| 22/05/21 17:00 | CA Osasuna | Real Sociedad | 0-1 |
| 22/05/21 17:00 | Celta Vigo | Real Betis Sevilla | 2-3 |
| 22/05/21 17:00 | FC Elche | Athletic Bilbao | 2-0 |
| 22/05/21 17:00 | SD Eibar | FC Barcelona | 0-1 |
| 23/05/21 17:30 | FC Granada | FC Getafe | 0-0 |
| 23/05/21 20:00 | FC Sevilla | Deportivo Alaves | 1-0 |