| Date | Home | Away | Result |
|---|---|---|---|
| 20/05/22 19:45 | FC Turin | AS Roma | 0-3 |
| 21/05/22 16:15 | FC Genua 1893 | FC Bologna | 0-1 |
| 21/05/22 19:45 | Lazio Rom | Hellas Verona | 3-3 |
| 21/05/22 19:45 | Fiorentina | Juventus Turin | 2-0 |
| 21/05/22 19:50 | Atalanta Bergamo | FC Empoli | 0-1 |
| 22/05/22 11:30 | Spezia Calcio | SSC Napoli | 0-3 |
| 22/05/22 17:00 | Sassuolo Calcio | AC Milan | 0-3 |
| 22/05/22 17:05 | Inter Milan | Sampdoria Genua | 3-0 |
| 22/05/22 20:00 | US Salernitana | Udinese Calcio | 0-4 |
| 22/05/22 20:00 | FC Venice | Cagliari Calcio | 0-0 |