| Date | Home | Away | Result |
|---|---|---|---|
| 22/05/21 19:45 | Cagliari Calcio | FC Genua 1893 | 0-1 |
| 22/05/21 19:45 | FC Crotone | Fiorentina | 0-0 |
| 22/05/21 19:45 | Sampdoria Genua | Parma Calcio 1913 | 3-0 |
| 23/05/21 14:00 | Inter Milan | Udinese Calcio | 5-1 |
| 23/05/21 19:45 | Spezia Calcio | AS Roma | 2-2 |
| 23/05/21 19:45 | Atalanta Bergamo | AC Milan | 0-2 |
| 23/05/21 19:45 | FC Bologna | Juventus Turin | 1-4 |
| 23/05/21 19:45 | Sassuolo Calcio | Lazio Rom | 2-0 |
| 23/05/21 19:45 | SSC Napoli | Hellas Verona | 1-1 |
| 23/05/21 19:45 | FC Turin | Benevento Calcio | 1-1 |