| Date | Home | Away | Result |
|---|---|---|---|
| 20/05/22 18:00 | Antalyaspor | Galatasaray Istanbul | 1-1 |
| 20/05/22 18:00 | Gazisehir Gaziantep FK | Caykur Rizespor | 2-0 |
| 21/05/22 14:00 | Altay SK | Kasimpasa Istanbul | 2-4 |
| 21/05/22 14:00 | Sivasspor | Kayserispor | 2-1 |
| 21/05/22 17:00 | Besiktas Istanbul | Konyaspor | 1-1 |
| 21/05/22 17:00 | Yeni Malatyaspor | Fenerbahce Istanbul | 0-5 |
| 22/05/22 14:00 | Fatih Karagümrük | Alanyaspor | 0-1 |
| 22/05/22 14:00 | Istanbul Basaksehir FK | Trabzonspor | 3-1 |
| 22/05/22 17:00 | Hatayspor | Giresunspor | 4-1 |
| 22/05/22 17:00 | Adana Demirspor | Göztepe Izmir | 7-0 |