| Date | Home | Away | Result |
|---|---|---|---|
| 22/05/22 16:00 | Chelsea FC | Watford FC | 2-1 |
| 22/05/22 16:00 | Crystal Palace | Manchester United | 1-0 |
| 22/05/22 16:00 | Leicester City | Southampton FC | 4-1 |
| 22/05/22 16:00 | Liverpool FC | Wolverhampton Wanderers | 3-1 |
| 22/05/22 16:00 | Manchester City | Aston Villa | 3-2 |
| 22/05/22 16:00 | Norwich City | Tottenham Hotspur | 0-5 |
| 22/05/22 16:00 | Arsenal FC | Everton FC | 5-1 |
| 22/05/22 16:00 | Brentford FC | Leeds United | 1-2 |
| 22/05/22 16:00 | Brighton and Hove Albion | West Ham United | 3-1 |
| 22/05/22 16:00 | Burnley FC | Newcastle United | 1-2 |