| Date | Home | Away | Result |
|---|---|---|---|
| 14/05/22 18:00 | FC Sochaux | Dijon FCO | 2-2 |
| 14/05/22 18:00 | AC Ajaccio | FC Toulouse | 1-0 |
| 14/05/22 18:00 | AJ Auxerre | Amiens SC | 2-1 |
| 14/05/22 18:00 | EA Guingamp | Havre AC | 2-1 |
| 14/05/22 18:00 | AS Nancy-Lorraine | Pau FC | 2-3 |
| 14/05/22 18:00 | Chamois Niortais FC | Valenciennes FC | 1-2 |
| 14/05/22 18:00 | Paris FC | Grenoble Foot | 2-0 |
| 14/05/22 18:00 | Nimes Olympique | SC Bastia | 0-2 |
| 14/05/22 18:00 | US Quevilly Rouen | USL Dunkerque | 3-1 |
| 14/05/22 18:00 | Rodez Aveyron | SM Caen | 2-0 |