| Date | Home | Away | Result |
|---|---|---|---|
| 15/05/21 19:00 | USL Dunkerque | FC Toulouse | 3-3 |
| 15/05/21 19:00 | Pau FC | Valenciennes FC | 4-3 |
| 15/05/21 19:00 | SM Caen | Clermont Foot | 2-1 |
| 15/05/21 19:00 | Chamois Niortais FC | EA Guingamp | 0-2 |
| 15/05/21 19:00 | LB Chateauroux | AC Ajaccio | 0-0 |
| 15/05/21 19:00 | Paris FC | FC Chambly | 3-0 |
| 15/05/21 19:00 | FC Sochaux | AJ Auxerre | 2-3 |
| 15/05/21 19:00 | AS Nancy-Lorraine | Amiens SC | 2-2 |
| 15/05/21 19:00 | Havre AC | ES Troyes AC | 3-2 |
| 15/05/21 19:00 | Grenoble Foot | Rodez Aveyron | 1-0 |