| Date | Home | Away | Result |
|---|---|---|---|
| 21/05/22 20:00 | OSC Lille | Stade Rennes | 2-2 |
| 21/05/22 20:00 | FC Lorient | ES Troyes AC | 1-1 |
| 21/05/22 20:00 | Olympique Marseille | Racing Club Strasbourg | 4-0 |
| 21/05/22 20:00 | FC Nantes | AS St. Etienne | 1-1 |
| 21/05/22 20:00 | Paris St. Germain | FC Metz | 5-0 |
| 21/05/22 20:00 | Stade Reims | OGC Nice | 2-3 |
| 21/05/22 20:00 | SCO Angers | HSC Montpellier | 2-0 |
| 21/05/22 20:00 | Stade Brest 29 | Girondins Bordeaux | 2-4 |
| 21/05/22 20:00 | Clermont Foot | Olympique Lyon | 1-2 |
| 21/05/22 20:00 | RC Lens | AS Monaco | 2-2 |