| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 22/04/22 19:30 | 22/04/22 19:25 | VfL Wolfsburg | FSV Mainz 05 | 5-0 | 2 - 4 points |
| 23/04/22 14:30 | 23/04/22 14:25 | RB Leipzig | 1. FC Union Berlin | 1-2 | 2 - 4 points |
| 23/04/22 14:30 | 23/04/22 14:25 | SpVgg Greuther Fürth | Bayer 04 Leverkusen | 1-4 | 2 - 4 points |
| 23/04/22 14:30 | 23/04/22 14:25 | 1. FC Köln | Arminia Bielefeld | 3-1 | 2 - 4 points |
| 23/04/22 14:30 | 23/04/22 14:25 | SC Freiburg | Bor. Mönchengladbach | 3-3 | 2 - 4 points |
| 23/04/22 14:30 | 23/04/22 14:25 | Eintracht Frankfurt | 1899 Hoffenheim | 2-2 | 2 - 4 points |
| 23/04/22 17:30 | 23/04/22 17:25 | FC Bayern Munich | Borussia Dortmund | 3-1 | 2 - 4 points |
| 24/04/22 14:30 | 24/04/22 14:25 | VfL Bochum | FC Augsburg | 0-2 | 2 - 4 points |
| 24/04/22 16:30 | 24/04/22 16:25 | Hertha BSC | VfB Stuttgart | 2-0 | 2 - 4 points |
