| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 12/03/22 14:30 | 12/03/22 14:25 | 1899 Hoffenheim | FC Bayern Munich | 1-1 | 2 - 4 points |
| 12/03/22 14:30 | 12/03/22 14:25 | SC Freiburg | VfL Wolfsburg | 3-2 | 2 - 4 points |
| 12/03/22 14:30 | 12/03/22 14:25 | 1. FC Union Berlin | VfB Stuttgart | 1-1 | 2 - 4 points |
| 12/03/22 17:30 | 12/03/22 17:25 | Bor. Mönchengladbach | Hertha BSC | 2-0 | 2 - 4 points |
| 13/03/22 14:30 | 13/03/22 14:25 | Bayer 04 Leverkusen | 1. FC Köln | 0-1 | 2 - 4 points |
| 13/03/22 16:30 | 13/03/22 16:25 | Borussia Dortmund | Arminia Bielefeld | 1-0 | 2 - 4 points |
| 13/03/22 16:30 | 13/03/22 16:25 | Eintracht Frankfurt | VfL Bochum | 2-1 | 2 - 4 points |
| 13/03/22 18:30 | 13/03/22 18:25 | SpVgg Greuther Fürth | RB Leipzig | 1-6 | 2 - 4 points |
| 06/04/22 17:30 | 06/04/22 17:25 | FC Augsburg | FSV Mainz 05 | 2-1 | 2 - 4 points |
