| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 11/02/22 19:30 | 11/02/22 19:25 | RB Leipzig | 1. FC Köln | 3-1 | 2 - 4 points |
| 12/02/22 14:30 | 12/02/22 14:25 | Bor. Mönchengladbach | FC Augsburg | 3-2 | 2 - 4 points |
| 12/02/22 14:30 | 12/02/22 14:25 | Eintracht Frankfurt | VfL Wolfsburg | 0-2 | 2 - 4 points |
| 12/02/22 14:30 | 12/02/22 14:25 | SpVgg Greuther Fürth | Hertha BSC | 2-1 | 2 - 4 points |
| 12/02/22 14:30 | 12/02/22 14:25 | VfL Bochum | FC Bayern Munich | 4-2 | 2 - 4 points |
| 12/02/22 14:30 | 12/02/22 14:25 | SC Freiburg | FSV Mainz 05 | 1-1 | 2 - 4 points |
| 12/02/22 17:30 | 12/02/22 17:25 | Bayer 04 Leverkusen | VfB Stuttgart | 4-2 | 2 - 4 points |
| 13/02/22 14:30 | 13/02/22 14:25 | 1. FC Union Berlin | Borussia Dortmund | 0-3 | 2 - 4 points |
| 13/02/22 16:30 | 13/02/22 16:25 | 1899 Hoffenheim | Arminia Bielefeld | 2-0 | 2 - 4 points |
