| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 21/01/22 19:30 | 21/01/22 19:25 | Eintracht Frankfurt | Arminia Bielefeld | 0-2 | 2 - 4 points |
| 22/01/22 14:30 | 22/01/22 14:25 | Bor. Mönchengladbach | 1. FC Union Berlin | 1-2 | 2 - 4 points |
| 22/01/22 14:30 | 22/01/22 14:25 | Bayer 04 Leverkusen | FC Augsburg | 5-1 | 2 - 4 points |
| 22/01/22 14:30 | 22/01/22 14:25 | 1899 Hoffenheim | Borussia Dortmund | 2-3 | 2 - 4 points |
| 22/01/22 14:30 | 22/01/22 14:25 | SC Freiburg | VfB Stuttgart | 2-0 | 2 - 4 points |
| 22/01/22 14:30 | 22/01/22 14:25 | SpVgg Greuther Fürth | FSV Mainz 05 | 2-1 | 2 - 4 points |
| 22/01/22 17:30 | 22/01/22 17:25 | VfL Bochum | 1. FC Köln | 2-2 | 2 - 4 points |
| 23/01/22 14:30 | 23/01/22 14:25 | RB Leipzig | VfL Wolfsburg | 2-0 | 2 - 4 points |
| 23/01/22 16:30 | 23/01/22 16:25 | Hertha BSC | FC Bayern Munich | 1-4 | 2 - 4 points |
