| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 14/12/21 17:30 | 14/12/21 17:25 | VfB Stuttgart | FC Bayern Munich | 0-5 | 2 - 4 points |
| 14/12/21 19:30 | 14/12/21 19:25 | Arminia Bielefeld | VfL Bochum | 2-0 | 2 - 4 points |
| 14/12/21 19:30 | 14/12/21 19:25 | FSV Mainz 05 | Hertha BSC | 4-0 | 2 - 4 points |
| 14/12/21 19:30 | 14/12/21 19:25 | VfL Wolfsburg | 1. FC Köln | 2-3 | 2 - 4 points |
| 15/12/21 17:30 | 15/12/21 17:25 | Bor. Mönchengladbach | Eintracht Frankfurt | 2-3 | 2 - 4 points |
| 15/12/21 19:30 | 15/12/21 19:25 | FC Augsburg | RB Leipzig | 1-1 | 2 - 4 points |
| 15/12/21 19:30 | 15/12/21 19:25 | 1. FC Union Berlin | SC Freiburg | 0-0 | 2 - 4 points |
| 15/12/21 19:30 | 15/12/21 19:25 | Bayer 04 Leverkusen | 1899 Hoffenheim | 2-2 | 2 - 4 points |
| 15/12/21 19:30 | 15/12/21 19:25 | Borussia Dortmund | SpVgg Greuther Fürth | 3-0 | 2 - 4 points |
