| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 13/08/21 19:30 | 13/08/21 19:25 | Bor. Mönchengladbach | FC Bayern Munich | 1-1 | 2 - 4 points |
| 14/08/21 14:30 | 14/08/21 14:25 | VfL Wolfsburg | VfL Bochum | 1-0 | 2 - 4 points |
| 14/08/21 14:30 | 14/08/21 14:25 | 1. FC Union Berlin | Bayer 04 Leverkusen | 1-1 | 2 - 4 points |
| 14/08/21 14:30 | 14/08/21 14:25 | VfB Stuttgart | SpVgg Greuther Fürth | 5-1 | 2 - 4 points |
| 14/08/21 14:30 | 14/08/21 14:25 | FC Augsburg | 1899 Hoffenheim | 0-4 | 2 - 4 points |
| 14/08/21 14:30 | 14/08/21 14:25 | Arminia Bielefeld | SC Freiburg | 0-0 | 2 - 4 points |
| 14/08/21 17:30 | 14/08/21 17:25 | Borussia Dortmund | Eintracht Frankfurt | 5-2 | 2 - 4 points |
| 15/08/21 14:30 | 15/08/21 14:25 | FSV Mainz 05 | RB Leipzig | 1-0 | 2 - 4 points |
| 15/08/21 16:30 | 15/08/21 16:25 | 1. FC Köln | Hertha BSC | 3-1 | 2 - 4 points |
