| Date | Home | Away | Result |
|---|---|---|---|
| 29/05/21 17:30 | CD Teneriffa | Real Oviedo | 2-2 |
| 30/05/21 17:30 | Albacete Balompie | CF Fuenlabrada | 1-2 |
| 30/05/21 20:00 | CD Mirandes | CD Sabadell | 0-2 |
| 30/05/21 20:00 | FC Cartagena | FC Girona | 1-1 |
| 30/05/21 20:00 | Rayo Vallecano | CD Lugo | 0-1 |
| 30/05/21 20:00 | FC Malaga | CD Castellon | 3-0 |
| 30/05/21 20:00 | SD Ponferradina | RCD Mallorca | 2-2 |
| 30/05/21 20:00 | AD Alcorcon | Espanyol Barcelona | 1-0 |
| 30/05/21 20:00 | UD Logrones | UD Las Palmas | 0-1 |
| 30/05/21 20:00 | Real Saragossa | CD Leganes | 0-5 |
| 30/05/21 20:00 | Sporting Gijon | UD Almeria | 0-2 |