| Date | Home | Away | Result |
|---|---|---|---|
| 16/05/21 12:00 | Dynamo Moscow | CSKA Moscow | 3-2 |
| 16/05/21 12:00 | FK Ufa | Arsenal Tula | 2-1 |
| 16/05/21 12:00 | FC Tambov | Zenit St. Petersburg | 1-5 |
| 16/05/21 12:00 | Rubin Kasan | Rotor Volgograd | 1-1 |
| 16/05/21 12:00 | FK Chimki | PFC Sochi | 0-0 |
| 16/05/21 12:00 | Lokomotive Moscow | Ural Jekaterinburg | 1-0 |
| 16/05/21 12:00 | Achmat Grosny | Spartak Moscow | 2-2 |
| 16/05/21 12:00 | FK Rostow | FK Krasnodar | 1-3 |