| Date | Home | Away | Result |
|---|---|---|---|
| 27/06/21 12:00 | TBV Lemgo | SC Magdeburg | 32-27 |
| 27/06/21 12:00 | HSC 2000 Coburg | TUSEM Essen | 31-32 |
| 27/06/21 14:30 | HSG Wetzlar | TSV GWD Minden | 28-25 |
| 27/06/21 14:30 | TSV Hannover-Burgdorf | SC DHfK Leipzig | 31-28 |
| 27/06/21 14:30 | HSG Nordhorn-Lingen | HC Erlangen | 30-31 |
| 27/06/21 14:30 | Füchse Berlin | Bergischer HC | 29-27 |
| 27/06/21 14:30 | Die Eulen Ludwigshafen | Frisch Auf Göppingen | 25-27 |
| 27/06/21 14:30 | Rhein-Neckar-Löwen | THW Kiel | 25-25 |
| 27/06/21 14:30 | SG Flensburg-Handewitt | HBW Balingen-Weilstetten | 38-26 |
| 27/06/21 14:30 | TVB 1898 Stuttgart | MT Melsungen | 26-26 |