| Date | Home | Away | Result |
|---|---|---|---|
| 08/05/16 13:30 | FC Utrecht | AZ Alkmaar | 1-3 |
| 08/05/16 13:30 | Feyenoord Rotterdam | NEC Nijmwegen | 1-0 |
| 08/05/16 13:30 | PEC Zwolle | PSV Eindhoven | 1-3 |
| 08/05/16 13:30 | De Graafschap Doetinchem | Ajax Amsterdam | 1-1 |
| 08/05/16 13:30 | FC Twente Enschede | Vitesse Arnheim | 2-2 |
| 08/05/16 13:30 | Roda JC Kerkrade | Willem II Tilburg | 2-3 |
| 08/05/16 13:30 | FC Groningen | Heracles Almelo | 2-1 |
| 08/05/16 13:30 | Cambuur-Leeuwarden | Excelsior Rotterdam | 0-2 |
| 08/05/16 13:30 | ADO Den Haag | SC Heerenveen | 1-1 |