Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/10/21 17:30 | 22/10/21 17:30 | Erzgebirge Aue | FC Ingolstadt | 1-0 | 2 - 4 points |
| 22/10/21 17:30 | 22/10/21 17:30 | SC Paderborn 07 | Hamburger SV | 1-2 | 2 - 4 points |
| 23/10/21 12:30 | 23/10/21 12:30 | 1. FC Nürnberg | 1. FC Heidenheim 1846 | 4-0 | 2 - 4 points |
| 23/10/21 12:30 | 23/10/21 12:30 | Holstein Kiel | SV Darmstadt 98 | 1-1 | 2 - 4 points |
| 23/10/21 12:30 | 23/10/21 12:30 | Fortuna Düsseldorf | Karlsruher SC | 3-1 | 2 - 4 points |
| 23/10/21 19:30 | 23/10/21 19:30 | FC Schalke 04 | Dynamo Dresden | 3-0 | 2 - 4 points |
| 24/10/21 12:30 | 24/10/21 12:30 | FC St. Pauli | FC Hansa Rostock | 4-0 | 2 - 4 points |
| 24/10/21 12:30 | 24/10/21 12:30 | Jahn Regensburg | Hannover 96 | 3-1 | 2 - 4 points |
| 24/10/21 12:30 | 24/10/21 12:30 | SV Sandhausen | Werder Bremen | 2-2 | 2 - 4 points |