| Date | Dead line | Home | Away | Result | Points rule |
|---|
| 07/01/22 19:30 | 07/01/22 19:00 | FC Bayern Munich | Bor. Mönchengladbach | 1-2 | 2 - 4 points |
| 08/01/22 14:30 | 08/01/22 14:00 | SpVgg Greuther Fürth | VfB Stuttgart | 0-0 | 2 - 4 points |
| 08/01/22 14:30 | 08/01/22 14:00 | 1899 Hoffenheim | FC Augsburg | 3-1 | 2 - 4 points |
| 08/01/22 14:30 | 08/01/22 14:00 | SC Freiburg | Arminia Bielefeld | 2-2 | 2 - 4 points |
| 08/01/22 14:30 | 08/01/22 14:00 | Bayer 04 Leverkusen | 1. FC Union Berlin | 2-2 | 2 - 4 points |
| 08/01/22 14:30 | 08/01/22 14:00 | RB Leipzig | FSV Mainz 05 | 4-1 | 2 - 4 points |
| 08/01/22 17:30 | 08/01/22 17:00 | Eintracht Frankfurt | Borussia Dortmund | 2-3 | 2 - 4 points |
| 09/01/22 14:30 | 09/01/22 14:00 | Hertha BSC | 1. FC Köln | 1-3 | 2 - 4 points |
| 09/01/22 16:30 | 09/01/22 16:00 | VfL Bochum | VfL Wolfsburg | 1-0 | 2 - 4 points |
