Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 09/12/21 17:45 | 09/12/21 17:45 | SSC Napoli | Leicester City | Group C | 3-2 | 5 - 7 points |
| 09/12/21 17:45 | 09/12/21 17:45 | Legia Warschau | Spartak Moscow | Group C | 0-1 | 5 - 7 points |
| 09/12/21 17:45 | 09/12/21 17:45 | Real Sociedad | PSV Eindhoven | Group B | 3-0 | 5 - 7 points |
| 09/12/21 17:45 | 09/12/21 17:45 | SK Sturm Graz | AS Monaco | Group B | 1-1 | 5 - 7 points |
| 09/12/21 17:45 | 09/12/21 17:45 | Fenerbahce Istanbul | Eintracht Frankfurt | Group D | 1-1 | 5 - 7 points |
| 09/12/21 17:45 | 09/12/21 17:45 | Royal Antwerp FC | Olympiakos Piräus | Group D | 1-0 | 5 - 7 points |
| 09/12/21 17:45 | 09/12/21 17:45 | Sparta Prag | Bröndby IF Copenhagen | Group A | 2-0 | 5 - 7 points |
| 09/12/21 17:45 | 09/12/21 17:45 | Olympique Lyon | Glasgow Rangers | Group A | 1-1 | 5 - 7 points |
| 09/12/21 20:00 | 09/12/21 20:00 | West Ham United | Dinamo Zagreb | Group H | 0-1 | 5 - 7 points |
| 09/12/21 20:00 | 09/12/21 20:00 | KRC Genk | SK Rapid Wien | Group H | 0-1 | 5 - 7 points |
| 09/12/21 20:00 | 09/12/21 20:00 | Ferencvaros Budapest | Bayer 04 Leverkusen | Group G | 1-0 | 5 - 7 points |
| 09/12/21 20:00 | 09/12/21 20:00 | Celtic Glasgow | Real Betis Sevilla | Group G | 3-2 | 5 - 7 points |
| 09/12/21 20:00 | 09/12/21 20:00 | Lazio Rom | Galatasaray Istanbul | Group E | 0-0 | 5 - 7 points |
| 09/12/21 20:00 | 09/12/21 20:00 | Olympique Marseille | Lokomotive Moscow | Group E | 1-0 | 5 - 7 points |
| 09/12/21 20:00 | 09/12/21 20:00 | Sporting Braga | Red Star Belgrad | Group F | 1-1 | 5 - 7 points |
| 09/12/21 20:00 | 09/12/21 20:00 | PFC Ludogorets Razgrad | FC Midtjylland | Group F | 0-0 | 5 - 7 points |