Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 15/09/21 15:30 | 15/09/21 15:30 | Spartak Moscow | Legia Warschau | Group C | 0-1 | 5 - 7 points |
| 16/09/21 17:45 | 16/09/21 17:45 | SK Rapid Wien | KRC Genk | Group H | 0-1 | 5 - 7 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Bayer 04 Leverkusen | Ferencvaros Budapest | Group G | 2-1 | 5 - 7 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Real Betis Sevilla | Celtic Glasgow | Group G | 4-3 | 5 - 7 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Galatasaray Istanbul | Lazio Rom | Group E | 1-0 | 5 - 7 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Lokomotive Moscow | Olympique Marseille | Group E | 1-1 | 5 - 7 points |
| 16/09/21 17:45 | 16/09/21 17:45 | FC Midtjylland | PFC Ludogorets Razgrad | Group F | 1-1 | 5 - 7 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Red Star Belgrad | Sporting Braga | Group F | 2-1 | 5 - 7 points |
| 16/09/21 17:45 | 16/09/21 17:45 | Dinamo Zagreb | West Ham United | Group H | 0-2 | 5 - 7 points |
| 16/09/21 20:00 | 16/09/21 20:00 | AS Monaco | SK Sturm Graz | Group B | 1-0 | 5 - 7 points |
| 16/09/21 20:00 | 16/09/21 20:00 | PSV Eindhoven | Real Sociedad | Group B | 2-2 | 5 - 7 points |
| 16/09/21 20:00 | 16/09/21 20:00 | Eintracht Frankfurt | Fenerbahce Istanbul | Group D | 1-1 | 5 - 7 points |
| 16/09/21 20:00 | 16/09/21 20:00 | Olympiakos Piräus | Royal Antwerp FC | Group D | 2-1 | 5 - 7 points |
| 16/09/21 20:00 | 16/09/21 20:00 | Glasgow Rangers | Olympique Lyon | Group A | 0-2 | 5 - 7 points |
| 16/09/21 20:00 | 16/09/21 20:00 | Bröndby IF Copenhagen | Sparta Prag | Group A | 0-0 | 5 - 7 points |
| 16/09/21 20:00 | 16/09/21 20:00 | Leicester City | SSC Napoli | Group C | 2-2 | 5 - 7 points |