| Date | Home | Away | Result |
|---|---|---|---|
| 21/01/25 15:30 | Galatasaray Istanbul | Dynamo Kiew | --- |
| 22/01/25 15:30 | Besiktas Istanbul | Athletic Bilbao | --- |
| 23/01/25 17:45 | AZ Alkmaar | AS Roma | --- |
| 23/01/25 17:45 | Malmö FF | FC Twente Enschede | --- |
| 23/01/25 17:45 | FK Bodö/Glimt | Maccabi Tel Aviv | --- |
| 23/01/25 17:45 | Qarabag | FCSB Bukarest | --- |
| 23/01/25 17:45 | Viktoria Plzen | RSC Anderlecht | --- |
| 23/01/25 17:45 | 1899 Hoffenheim | Tottenham Hotspur | --- |
| 23/01/25 17:45 | FC Porto | Olympiakos Piräus | --- |
| 23/01/25 17:45 | Fenerbahce Istanbul | Olympique Lyon | --- |
| 23/01/25 20:00 | Rigas Futbola Skola | Ajax Amsterdam | --- |
| 23/01/25 20:00 | PFC Ludogorets Razgrad | FC Midtjylland | --- |
| 23/01/25 20:00 | Royale Union Saint-Gilloise | Sporting Braga | --- |
| 23/01/25 20:00 | IF Elfsborg Boras | OGC Nice | --- |
| 23/01/25 20:00 | Eintracht Frankfurt | Ferencvaros Budapest | --- |
| 23/01/25 20:00 | Manchester United | Glasgow Rangers | --- |
| 23/01/25 20:00 | Lazio Rom | Real Sociedad | --- |
| 23/01/25 20:00 | PAOK Saloniki | Slavia Prag | --- |