| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 27/10/22 17:45 | 1. FC Union Berlin | Sporting Braga | Group D | 1-0 |
| 27/10/22 17:45 | Malmö FF | Royale Union Saint-Gilloise | Group D | 0-2 |
| 27/10/22 17:45 | PFC Ludogorets Razgrad | Real Betis Sevilla | Group C | 0-1 |
| 27/10/22 17:45 | Lazio Rom | FC Midtjylland | Group F | 2-1 |
| 27/10/22 17:45 | AEK Larnaka | Dynamo Kiew | Group B | 3-3 |
| 27/10/22 17:45 | Fenerbahce Istanbul | Stade Rennes | Group B | 3-3 |
| 27/10/22 17:45 | PSV Eindhoven | Arsenal FC | Group A | 2-0 |
| 27/10/22 17:45 | FC Zürich | FK Bodö/Glimt | Group A | 2-1 |
| 27/10/22 20:00 | Manchester United | Sheriff Tiraspol | Group E | 3-0 |
| 27/10/22 20:00 | Omonia Nicosia | Real Sociedad | Group E | 0-2 |
| 27/10/22 20:00 | Red Star Belgrad | Trabzonspor | Group H | 2-1 |
| 27/10/22 20:00 | Ferencvaros Budapest | AS Monaco | Group H | 1-1 |
| 27/10/22 20:00 | HJK Helsinki | AS Roma | Group C | 1-2 |
| 27/10/22 20:00 | FC Nantes | Qarabag | Group G | 2-1 |
| 27/10/22 20:00 | SC Freiburg | Olympiakos Piräus | Group G | 1-1 |
| 27/10/22 20:05 | SK Sturm Graz | Feyenoord Rotterdam | Group F | 1-0 |