| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 13/10/22 17:45 | Real Betis Sevilla | AS Roma | Group C | 1-1 |
| 13/10/22 17:45 | Feyenoord Rotterdam | FC Midtjylland | Group F | 2-2 |
| 13/10/22 17:45 | Dynamo Kiew | Stade Rennes | Group B | 0-1 |
| 13/10/22 17:45 | AEK Larnaka | Fenerbahce Istanbul | Group B | 1-2 |
| 13/10/22 17:45 | Qarabag | Olympiakos Piräus | Group G | 0-0 |
| 13/10/22 17:45 | FC Nantes | SC Freiburg | Group G | 0-4 |
| 13/10/22 17:45 | FK Bodö/Glimt | Arsenal FC | Group A | 0-1 |
| 13/10/22 17:45 | Royale Union Saint-Gilloise | Sporting Braga | Group D | 3-3 |
| 13/10/22 20:00 | 1. FC Union Berlin | Malmö FF | Group D | 1-0 |
| 13/10/22 20:00 | Real Sociedad | Sheriff Tiraspol | Group E | 3-0 |
| 13/10/22 20:00 | Manchester United | Omonia Nicosia | Group E | 1-0 |
| 13/10/22 20:00 | Trabzonspor | AS Monaco | Group H | 4-0 |
| 13/10/22 20:00 | Ferencvaros Budapest | Red Star Belgrad | Group H | 2-1 |
| 13/10/22 20:00 | PFC Ludogorets Razgrad | HJK Helsinki | Group C | 2-0 |
| 13/10/22 20:00 | Lazio Rom | SK Sturm Graz | Group F | 2-2 |
| 13/10/22 20:00 | PSV Eindhoven | FC Zürich | Group A | 5-0 |