| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 06/10/22 17:45 | Sheriff Tiraspol | Real Sociedad | Group E | 0-2 |
| 06/10/22 17:45 | Omonia Nicosia | Manchester United | Group E | 2-3 |
| 06/10/22 17:45 | AS Monaco | Trabzonspor | Group H | 3-1 |
| 06/10/22 17:45 | Red Star Belgrad | Ferencvaros Budapest | Group H | 4-1 |
| 06/10/22 17:45 | HJK Helsinki | PFC Ludogorets Razgrad | Group C | 1-1 |
| 06/10/22 17:45 | SK Sturm Graz | Lazio Rom | Group F | 0-0 |
| 06/10/22 17:45 | FC Zürich | PSV Eindhoven | Group A | 1-5 |
| 06/10/22 17:45 | Malmö FF | 1. FC Union Berlin | Group D | 0-1 |
| 06/10/22 20:00 | AS Roma | Real Betis Sevilla | Group C | 1-2 |
| 06/10/22 20:00 | FC Midtjylland | Feyenoord Rotterdam | Group F | 2-2 |
| 06/10/22 20:00 | Stade Rennes | Dynamo Kiew | Group B | 2-1 |
| 06/10/22 20:00 | Fenerbahce Istanbul | AEK Larnaka | Group B | 2-0 |
| 06/10/22 20:00 | SC Freiburg | FC Nantes | Group G | 2-0 |
| 06/10/22 20:00 | Olympiakos Piräus | Qarabag | Group G | 0-3 |
| 06/10/22 20:00 | Arsenal FC | FK Bodö/Glimt | Group A | 3-0 |
| 06/10/22 20:00 | Sporting Braga | Royale Union Saint-Gilloise | Group D | 1-2 |