| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 08/09/22 17:45 | PFC Ludogorets Razgrad | AS Roma | Group C | 2-1 |
| 08/09/22 17:45 | HJK Helsinki | Real Betis Sevilla | Group C | 0-2 |
| 08/09/22 17:45 | AEK Larnaka | Stade Rennes | Group B | 1-2 |
| 08/09/22 17:45 | Fenerbahce Istanbul | Dynamo Kiew | Group B | 2-1 |
| 08/09/22 17:45 | PSV Eindhoven | FK Bodö/Glimt | Group A | 1-1 |
| 08/09/22 17:45 | FC Zürich | Arsenal FC | Group A | 1-2 |
| 08/09/22 17:45 | Malmö FF | Sporting Braga | Group D | 0-2 |
| 08/09/22 17:45 | 1. FC Union Berlin | Royale Union Saint-Gilloise | Group D | 0-1 |
| 08/09/22 20:00 | Red Star Belgrad | AS Monaco | Group H | 0-1 |
| 08/09/22 20:00 | Ferencvaros Budapest | Trabzonspor | Group H | 3-2 |
| 08/09/22 20:00 | Lazio Rom | Feyenoord Rotterdam | Group F | 4-2 |
| 08/09/22 20:00 | SK Sturm Graz | FC Midtjylland | Group F | 1-0 |
| 08/09/22 20:00 | FC Nantes | Olympiakos Piräus | Group G | 2-1 |
| 08/09/22 20:00 | SC Freiburg | Qarabag | Group G | 2-1 |
| 08/09/22 20:00 | Manchester United | Real Sociedad | Group E | 0-1 |
| 08/09/22 20:00 | Omonia Nicosia | Sheriff Tiraspol | Group E | 0-3 |