Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 18/01/22 17:30 | 18/01/22 17:30 | 1. FC Köln | Hamburger SV | 4-5a.PSO | 2 - 4 points |
| 18/01/22 17:30 | 18/01/22 17:30 | TSV 1860 Munich | Karlsruher SC | 0-1 | 2 - 4 points |
| 18/01/22 19:45 | 18/01/22 19:45 | FC St. Pauli | Borussia Dortmund | 2-1 | 2 - 4 points |
| 18/01/22 19:45 | 18/01/22 19:45 | VfL Bochum | FSV Mainz 05 | 3-1 | 2 - 4 points |
| 19/01/22 17:30 | 19/01/22 17:30 | Hannover 96 | Bor. Mönchengladbach | 3-0 | 2 - 4 points |
| 19/01/22 17:30 | 19/01/22 17:30 | RB Leipzig | FC Hansa Rostock | 2-0 | 2 - 4 points |
| 19/01/22 19:45 | 19/01/22 19:45 | 1899 Hoffenheim | SC Freiburg | 1-4 | 2 - 4 points |
| 19/01/22 19:45 | 19/01/22 19:45 | Hertha BSC | 1. FC Union Berlin | 2-3 | 2 - 4 points |