Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/09/21 18:00 | 17/09/21 18:00 | TSV Havelse | FC Viktoria Köln | 1-0 | 5 - 7 points |
| 18/09/21 13:00 | 18/09/21 13:00 | MSV Duisburg | Eintracht Braunschweig | 3-2 | 5 - 7 points |
| 18/09/21 13:00 | 18/09/21 13:00 | 1. FC Magdeburg | FC Würzburger Kickers | 1-2 | 5 - 7 points |
| 18/09/21 13:00 | 18/09/21 13:00 | 1. FC Saarbrücken | Türkgücü München | 3-1 | 5 - 7 points |
| 18/09/21 13:00 | 18/09/21 13:00 | TSV 1860 Munich | FSV Zwickau | 0-2 | 5 - 7 points |
| 18/09/21 13:00 | 18/09/21 13:00 | SV Waldhof Mannheim | Hallescher FC | 2-1 | 5 - 7 points |
| 18/09/21 13:00 | 18/09/21 13:00 | VfL Osnabrück | SV Meppen | 1-0 | 5 - 7 points |
| 19/09/21 12:00 | 19/09/21 12:00 | SC Freiburg II | Viktoria 1889 Berlin | 2-0 | 5 - 7 points |
| 19/09/21 13:00 | 19/09/21 13:00 | SC Verl | 1. FC Kaiserslautern | 0-2 | 5 - 7 points |
| 20/09/21 18:00 | 20/09/21 18:00 | SV Wehen Wiesbaden | Borussia Dortmund II | 0-1 | 5 - 7 points |