Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/09/21 18:00 | 10/09/21 18:00 | SV Meppen | SC Freiburg II | 0-1 | 5 - 7 points |
| 11/09/21 13:00 | 11/09/21 13:00 | FC Würzburger Kickers | TSV Havelse | 0-0 | 5 - 7 points |
| 11/09/21 13:00 | 11/09/21 13:00 | Viktoria 1889 Berlin | SV Wehen Wiesbaden | 3-1 | 5 - 7 points |
| 11/09/21 13:00 | 11/09/21 13:00 | 1. FC Kaiserslautern | SV Waldhof Mannheim | 0-0 | 5 - 7 points |
| 11/09/21 13:00 | 11/09/21 13:00 | Borussia Dortmund II | 1. FC Magdeburg | 0-2 | 5 - 7 points |
| 11/09/21 13:00 | 11/09/21 13:00 | FSV Zwickau | SC Verl | 1-3 | 5 - 7 points |
| 11/09/21 13:00 | 11/09/21 13:00 | FC Viktoria Köln | 1. FC Saarbrücken | 0-0 | 5 - 7 points |
| 12/09/21 12:00 | 12/09/21 12:00 | Hallescher FC | TSV 1860 Munich | 1-1 | 5 - 7 points |
| 12/09/21 13:00 | 12/09/21 13:00 | Eintracht Braunschweig | VfL Osnabrück | 2-2 | 5 - 7 points |
| 13/09/21 18:00 | 13/09/21 18:00 | Türkgücü München | MSV Duisburg | 1-0 | 5 - 7 points |