Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 27/08/21 18:00 | 27/08/21 18:00 | Hallescher FC | SC Verl | 4-4 | 5 - 7 points |
| 28/08/21 13:00 | 28/08/21 13:00 | Eintracht Braunschweig | TSV 1860 Munich | 1-1 | 5 - 7 points |
| 28/08/21 13:00 | 28/08/21 13:00 | SV Wehen Wiesbaden | 1. FC Magdeburg | 2-4 | 5 - 7 points |
| 28/08/21 13:00 | 28/08/21 13:00 | Viktoria 1889 Berlin | SV Waldhof Mannheim | 1-0 | 5 - 7 points |
| 28/08/21 13:00 | 28/08/21 13:00 | 1. FC Kaiserslautern | FSV Zwickau | 1-1 | 5 - 7 points |
| 28/08/21 13:00 | 28/08/21 13:00 | FC Viktoria Köln | SC Freiburg II | 3-1 | 5 - 7 points |
| 28/08/21 13:00 | 28/08/21 13:00 | Türkgücü München | VfL Osnabrück | 0-3 | 5 - 7 points |
| 29/08/21 12:00 | 29/08/21 12:00 | Borussia Dortmund II | MSV Duisburg | 4-1 | 5 - 7 points |
| 29/08/21 13:00 | 29/08/21 13:00 | FC Würzburger Kickers | 1. FC Saarbrücken | 1-1 | 5 - 7 points |
| 30/08/21 18:00 | 30/08/21 18:00 | SV Meppen | TSV Havelse | 1-0 | 5 - 7 points |