Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 24/08/21 18:00 | 24/08/21 18:00 | Hallescher FC | 1. FC Kaiserslautern | 1-0 | 5 - 7 points |
| 24/08/21 18:00 | 24/08/21 18:00 | TSV 1860 Munich | FC Viktoria Köln | 3-0 | 5 - 7 points |
| 24/08/21 18:00 | 24/08/21 18:00 | SV Waldhof Mannheim | SV Meppen | 5-0 | 5 - 7 points |
| 24/08/21 18:00 | 24/08/21 18:00 | FSV Zwickau | Viktoria 1889 Berlin | 1-1 | 5 - 7 points |
| 24/08/21 18:00 | 24/08/21 18:00 | SC Verl | Eintracht Braunschweig | 0-3 | 5 - 7 points |
| 25/08/21 18:00 | 25/08/21 18:00 | VfL Osnabrück | Borussia Dortmund II | 2-1 | 5 - 7 points |
| 25/08/21 18:00 | 25/08/21 18:00 | SC Freiburg II | FC Würzburger Kickers | 1-0 | 5 - 7 points |
| 25/08/21 18:00 | 25/08/21 18:00 | MSV Duisburg | SV Wehen Wiesbaden | 0-2 | 5 - 7 points |
| 25/08/21 18:00 | 25/08/21 18:00 | TSV Havelse | Türkgücü München | 0-3 | 5 - 7 points |
| 25/08/21 18:00 | 25/08/21 18:00 | 1. FC Saarbrücken | 1. FC Magdeburg | 2-1 | 5 - 7 points |