Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 06/05/22 18:00 | 06/05/22 18:00 | Borussia Dortmund II | SC Verl | 1-2 | 5 - 7 points |
| 07/05/22 13:00 | 07/05/22 13:00 | 1. FC Magdeburg | TSV 1860 Munich | 4-0 | 5 - 7 points |
| 07/05/22 13:00 | 07/05/22 13:00 | SV Meppen | Eintracht Braunschweig | 3-2 | 5 - 7 points |
| 07/05/22 13:00 | 07/05/22 13:00 | MSV Duisburg | SC Freiburg II | 1-0 | 5 - 7 points |
| 07/05/22 13:00 | 07/05/22 13:00 | SV Wehen Wiesbaden | SV Waldhof Mannheim | 1-1 | 5 - 7 points |
| 07/05/22 13:00 | 07/05/22 13:00 | TSV Havelse | VfL Osnabrück | 0-1 | 5 - 7 points |
| 07/05/22 13:00 | 07/05/22 13:00 | 1. FC Saarbrücken | FSV Zwickau | 1-1 | 5 - 7 points |
| 08/05/22 12:00 | 08/05/22 12:00 | FC Würzburger Kickers | Hallescher FC | 1-2 | 5 - 7 points |
| 08/05/22 13:00 | 08/05/22 13:00 | FC Viktoria Köln | 1. FC Kaiserslautern | 2-0 | 5 - 7 points |