Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 16/04/22 13:00 | 16/04/22 13:00 | FSV Zwickau | SV Wehen Wiesbaden | 2-1 | 5 - 7 points |
| 16/04/22 13:00 | 16/04/22 13:00 | SV Meppen | Borussia Dortmund II | 1-1 | 5 - 7 points |
| 16/04/22 13:00 | 16/04/22 13:00 | Eintracht Braunschweig | FC Würzburger Kickers | 1-0 | 5 - 7 points |
| 16/04/22 13:00 | 16/04/22 13:00 | TSV 1860 Munich | VfL Osnabrück | 2-3 | 5 - 7 points |
| 16/04/22 13:00 | 16/04/22 13:00 | Viktoria 1889 Berlin | MSV Duisburg | 0-1 | 5 - 7 points |
| 16/04/22 13:00 | 16/04/22 13:00 | Hallescher FC | TSV Havelse | 1-1 | 5 - 7 points |
| 17/04/22 12:00 | 17/04/22 12:00 | SC Verl | 1. FC Magdeburg | 4-5 | 5 - 7 points |
| 17/04/22 13:00 | 17/04/22 13:00 | 1. FC Kaiserslautern | 1. FC Saarbrücken | 3-1 | 5 - 7 points |
| 18/04/22 18:00 | 18/04/22 18:00 | SV Waldhof Mannheim | SC Freiburg II | 0-1 | 5 - 7 points |