Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 13/08/21 18:00 | 13/08/21 18:00 | SC Freiburg II | Borussia Dortmund II | 2-5 | 5 - 7 points |
| 14/08/21 13:00 | 14/08/21 13:00 | VfL Osnabrück | SV Wehen Wiesbaden | 0-1 | 5 - 7 points |
| 14/08/21 13:00 | 14/08/21 13:00 | TSV 1860 Munich | Türkgücü München | 1-1 | 5 - 7 points |
| 14/08/21 13:00 | 14/08/21 13:00 | TSV Havelse | 1. FC Magdeburg | 1-3 | 5 - 7 points |
| 14/08/21 13:00 | 14/08/21 13:00 | 1. FC Saarbrücken | MSV Duisburg | 2-0 | 5 - 7 points |
| 14/08/21 13:00 | 14/08/21 13:00 | FSV Zwickau | SV Meppen | 1-1 | 5 - 7 points |
| 14/08/21 13:00 | 14/08/21 13:00 | SC Verl | FC Viktoria Köln | 3-1 | 5 - 7 points |
| 15/08/21 12:00 | 15/08/21 12:00 | Viktoria 1889 Berlin | 1. FC Kaiserslautern | 4-0 | 5 - 7 points |
| 15/08/21 13:00 | 15/08/21 13:00 | SV Waldhof Mannheim | FC Würzburger Kickers | 1-1 | 5 - 7 points |
| 16/08/21 18:00 | 16/08/21 18:00 | Hallescher FC | Eintracht Braunschweig | 0-2 | 5 - 7 points |