Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/02/22 18:00 | 25/02/22 18:00 | FC Viktoria Köln | TSV Havelse | 0-0 | 5 - 7 points |
| 26/02/22 13:00 | 26/02/22 13:00 | FC Würzburger Kickers | 1. FC Magdeburg | 2-4 | 5 - 7 points |
| 26/02/22 13:00 | 26/02/22 13:00 | Eintracht Braunschweig | MSV Duisburg | 2-1 | 5 - 7 points |
| 26/02/22 13:00 | 26/02/22 13:00 | Hallescher FC | SV Waldhof Mannheim | 1-2 | 5 - 7 points |
| 26/02/22 13:00 | 26/02/22 13:00 | FSV Zwickau | TSV 1860 Munich | 1-3 | 5 - 7 points |
| 26/02/22 13:00 | 26/02/22 13:00 | SV Meppen | VfL Osnabrück | 0-1 | 5 - 7 points |
| 26/02/22 13:00 | 26/02/22 13:00 | 1. FC Kaiserslautern | SC Verl | 2-1 | 5 - 7 points |
| 27/02/22 12:00 | 27/02/22 12:00 | Viktoria 1889 Berlin | SC Freiburg II | 0-2 | 5 - 7 points |
| 27/02/22 13:00 | 27/02/22 13:00 | Borussia Dortmund II | SV Wehen Wiesbaden | 2-3 | 5 - 7 points |
| 28/02/22 18:00 | 28/02/22 18:00 | Türkgücü München | 1. FC Saarbrücken | 1-5 | 5 - 7 points |