Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/02/22 18:00 | 04/02/22 18:00 | SC Freiburg II | FC Viktoria Köln | 1-1 | 5 - 7 points |
| 05/02/22 13:00 | 05/02/22 13:00 | TSV Havelse | SV Meppen | 3-0 | 5 - 7 points |
| 05/02/22 13:00 | 05/02/22 13:00 | 1. FC Magdeburg | SV Wehen Wiesbaden | 3-1 | 5 - 7 points |
| 05/02/22 13:00 | 05/02/22 13:00 | SV Waldhof Mannheim | Viktoria 1889 Berlin | 3-2 | 5 - 7 points |
| 05/02/22 13:00 | 05/02/22 13:00 | FSV Zwickau | 1. FC Kaiserslautern | 0-2 | 5 - 7 points |
| 05/02/22 13:00 | 05/02/22 13:00 | SC Verl | Hallescher FC | 0-0 | 5 - 7 points |
| 05/02/22 13:00 | 05/02/22 13:00 | VfL Osnabrück | Türkgücü München | 1-1 | 5 - 7 points |
| 06/02/22 12:00 | 06/02/22 12:00 | TSV 1860 Munich | Eintracht Braunschweig | 2-2 | 5 - 7 points |
| 06/02/22 13:00 | 06/02/22 13:00 | MSV Duisburg | Borussia Dortmund II | 1-3 | 5 - 7 points |
| 07/02/22 18:00 | 07/02/22 18:00 | 1. FC Saarbrücken | FC Würzburger Kickers | 2-1 | 5 - 7 points |