Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/01/22 18:00 | 25/01/22 18:00 | VfL Osnabrück | FC Würzburger Kickers | 2-0 | 5 - 7 points |
| 25/01/22 18:00 | 25/01/22 18:00 | SC Freiburg II | Türkgücü München | 4-2 | 5 - 7 points |
| 25/01/22 18:00 | 25/01/22 18:00 | SV Waldhof Mannheim | FC Viktoria Köln | 0-1 | 5 - 7 points |
| 26/01/22 18:00 | 26/01/22 18:00 | FSV Zwickau | Eintracht Braunschweig | 1-0 | 5 - 7 points |
| 26/01/22 18:00 | 26/01/22 18:00 | SC Verl | SV Meppen | 0-1 | 5 - 7 points |
| 26/01/22 18:00 | 26/01/22 18:00 | MSV Duisburg | 1. FC Magdeburg | 0-5 | 5 - 7 points |
| 26/01/22 18:00 | 26/01/22 18:00 | TSV Havelse | SV Wehen Wiesbaden | 0-1 | 5 - 7 points |
| 26/01/22 18:00 | 26/01/22 18:00 | 1. FC Saarbrücken | Borussia Dortmund II | 2-0 | 5 - 7 points |
| 01/03/22 18:00 | 01/03/22 18:00 | TSV 1860 Munich | 1. FC Kaiserslautern | 2-1 | 5 - 7 points |
| 02/03/22 18:00 | 02/03/22 18:00 | Hallescher FC | Viktoria 1889 Berlin | 4-1 | 5 - 7 points |