Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 03/12/21 18:00 | 03/12/21 18:00 | FSV Zwickau | 1. FC Saarbrücken | 1-2 | 5 - 7 points |
| 04/12/21 13:00 | 04/12/21 13:00 | SC Verl | Borussia Dortmund II | 0-3 | 5 - 7 points |
| 04/12/21 13:00 | 04/12/21 13:00 | TSV 1860 Munich | 1. FC Magdeburg | 2-5 | 5 - 7 points |
| 04/12/21 13:00 | 04/12/21 13:00 | 1. FC Kaiserslautern | FC Viktoria Köln | 4-0 | 5 - 7 points |
| 04/12/21 13:00 | 04/12/21 13:00 | Hallescher FC | FC Würzburger Kickers | 0-0 | 5 - 7 points |
| 04/12/21 13:00 | 04/12/21 13:00 | Viktoria 1889 Berlin | Türkgücü München | 0-0 | 5 - 7 points |
| 04/12/21 13:00 | 04/12/21 13:00 | Eintracht Braunschweig | SV Meppen | 5-0 | 5 - 7 points |
| 05/12/21 12:00 | 05/12/21 12:00 | SC Freiburg II | MSV Duisburg | 1-0 | 5 - 7 points |
| 05/12/21 13:00 | 05/12/21 13:00 | VfL Osnabrück | TSV Havelse | 0-0 | 5 - 7 points |
| 06/12/21 18:00 | 06/12/21 18:00 | SV Waldhof Mannheim | SV Wehen Wiesbaden | 1-1 | 5 - 7 points |