Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 19/11/21 18:00 | 19/11/21 18:00 | SC Verl | 1. FC Saarbrücken | 2-4 | 5 - 7 points |
| 20/11/21 13:00 | 20/11/21 13:00 | Eintracht Braunschweig | Türkgücü München | 2-0 | 5 - 7 points |
| 20/11/21 13:00 | 20/11/21 13:00 | 1. FC Kaiserslautern | SV Wehen Wiesbaden | 1-0 | 5 - 7 points |
| 20/11/21 13:00 | 20/11/21 13:00 | Hallescher FC | Borussia Dortmund II | 1-2 | 5 - 7 points |
| 20/11/21 13:00 | 20/11/21 13:00 | SC Freiburg II | TSV Havelse | 0-0 | 5 - 7 points |
| 20/11/21 13:00 | 20/11/21 13:00 | TSV 1860 Munich | MSV Duisburg | 3-2 | 5 - 7 points |
| 21/11/21 12:00 | 21/11/21 12:00 | Viktoria 1889 Berlin | FC Würzburger Kickers | 1-1 | 5 - 7 points |
| 21/11/21 13:00 | 21/11/21 13:00 | SV Waldhof Mannheim | VfL Osnabrück | 3-3 | 5 - 7 points |
| 22/11/21 18:00 | 22/11/21 18:00 | SV Meppen | FC Viktoria Köln | 4-0 | 5 - 7 points |
| 15/12/21 18:00 | 15/12/21 18:00 | FSV Zwickau | 1. FC Magdeburg | 1-1 | 5 - 7 points |