Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 15/10/21 18:00 | 15/10/21 18:00 | Viktoria 1889 Berlin | VfL Osnabrück | 1-2 | 5 - 7 points |
| 16/10/21 13:00 | 16/10/21 13:00 | 1. FC Kaiserslautern | SC Freiburg II | 3-0 | 5 - 7 points |
| 16/10/21 13:00 | 16/10/21 13:00 | FSV Zwickau | MSV Duisburg | 3-2 | 5 - 7 points |
| 16/10/21 13:00 | 16/10/21 13:00 | SV Meppen | 1. FC Magdeburg | 2-3 | 5 - 7 points |
| 16/10/21 13:00 | 16/10/21 13:00 | Hallescher FC | 1. FC Saarbrücken | 2-3 | 5 - 7 points |
| 16/10/21 13:00 | 16/10/21 13:00 | Eintracht Braunschweig | Borussia Dortmund II | 4-2 | 5 - 7 points |
| 17/10/21 12:00 | 17/10/21 12:00 | Türkgücü München | SV Wehen Wiesbaden | 1-0 | 5 - 7 points |
| 17/10/21 13:00 | 17/10/21 13:00 | FC Viktoria Köln | FC Würzburger Kickers | 1-1 | 5 - 7 points |
| 18/10/21 18:00 | 18/10/21 18:00 | SC Verl | TSV Havelse | 5-3 | 5 - 7 points |
| 30/11/21 18:00 | 30/11/21 18:00 | TSV 1860 Munich | SV Waldhof Mannheim | 1-3 | 5 - 7 points |