Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 07/12/21 17:45 | 07/12/21 17:45 | RB Leipzig | Manchester City | Group A | 2-1 | 5 - 7 points |
| 07/12/21 17:45 | 07/12/21 17:45 | Paris St. Germain | Club Brugge | Group A | 4-1 | 5 - 7 points |
| 07/12/21 20:00 | 07/12/21 20:00 | Schachtjor Donezk | Sheriff Tiraspol | Group D | 1-1 | 5 - 7 points |
| 07/12/21 20:00 | 07/12/21 20:00 | Real Madrid | Inter Milan | Group D | 2-0 | 5 - 7 points |
| 07/12/21 20:00 | 07/12/21 20:00 | FC Porto | Atletico Madrid | Group B | 1-3 | 5 - 7 points |
| 07/12/21 20:00 | 07/12/21 20:00 | AC Milan | Liverpool FC | Group B | 1-2 | 5 - 7 points |
| 07/12/21 20:00 | 07/12/21 20:00 | Borussia Dortmund | Besiktas Istanbul | Group C | 5-0 | 5 - 7 points |
| 07/12/21 20:00 | 07/12/21 20:00 | Ajax Amsterdam | Sporting Lisbon | Group C | 4-2 | 5 - 7 points |
| 08/12/21 17:45 | 08/12/21 17:45 | Juventus Turin | Malmö FF | Group H | 1-0 | 5 - 7 points |
| 08/12/21 17:45 | 08/12/21 17:45 | Zenit St. Petersburg | Chelsea FC | Group H | 3-3 | 5 - 7 points |
| 08/12/21 20:00 | 08/12/21 20:00 | Manchester United | Young Boys Bern | Group F | 1-1 | 5 - 7 points |
| 08/12/21 20:00 | 08/12/21 20:00 | FC Red Bull Salzburg | FC Sevilla | Group G | 1-0 | 5 - 7 points |
| 08/12/21 20:00 | 08/12/21 20:00 | VfL Wolfsburg | OSC Lille | Group G | 1-3 | 5 - 7 points |
| 08/12/21 20:00 | 08/12/21 20:00 | Benfica Lisbon | Dynamo Kiew | Group E | 2-0 | 5 - 7 points |
| 08/12/21 20:00 | 08/12/21 20:00 | FC Bayern Munich | FC Barcelona | Group E | 3-0 | 5 - 7 points |
| 09/12/21 18:00 | 09/12/21 18:00 | Atalanta Bergamo | FC Villarreal | Group F | 2-3 | 5 - 7 points |