Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 02/11/21 17:45 | 02/11/21 17:45 | Malmö FF | Chelsea FC | Group H | 0-1 | 5 - 7 points |
| 02/11/21 17:45 | 02/11/21 17:45 | VfL Wolfsburg | FC Red Bull Salzburg | Group G | 2-1 | 5 - 7 points |
| 02/11/21 20:00 | 02/11/21 20:00 | Juventus Turin | Zenit St. Petersburg | Group H | 4-2 | 5 - 7 points |
| 02/11/21 20:00 | 02/11/21 20:00 | FC Sevilla | OSC Lille | Group G | 1-2 | 5 - 7 points |
| 02/11/21 20:00 | 02/11/21 20:00 | FC Bayern Munich | Benfica Lisbon | Group E | 5-2 | 5 - 7 points |
| 02/11/21 20:00 | 02/11/21 20:00 | Dynamo Kiew | FC Barcelona | Group E | 0-1 | 5 - 7 points |
| 02/11/21 20:00 | 02/11/21 20:00 | Atalanta Bergamo | Manchester United | Group F | 2-2 | 5 - 7 points |
| 02/11/21 20:00 | 02/11/21 20:00 | FC Villarreal | Young Boys Bern | Group F | 2-0 | 5 - 7 points |
| 03/11/21 17:45 | 03/11/21 17:45 | Real Madrid | Schachtjor Donezk | Group D | 2-1 | 5 - 7 points |
| 03/11/21 17:45 | 03/11/21 17:45 | AC Milan | FC Porto | Group B | 1-1 | 5 - 7 points |
| 03/11/21 20:00 | 03/11/21 20:00 | Sheriff Tiraspol | Inter Milan | Group D | 1-3 | 5 - 7 points |
| 03/11/21 20:00 | 03/11/21 20:00 | Liverpool FC | Atletico Madrid | Group B | 2-0 | 5 - 7 points |
| 03/11/21 20:00 | 03/11/21 20:00 | Manchester City | Club Brugge | Group A | 4-1 | 5 - 7 points |
| 03/11/21 20:00 | 03/11/21 20:00 | RB Leipzig | Paris St. Germain | Group A | 2-2 | 5 - 7 points |
| 03/11/21 20:00 | 03/11/21 20:00 | Sporting Lisbon | Besiktas Istanbul | Group C | 4-0 | 5 - 7 points |
| 03/11/21 20:00 | 03/11/21 20:00 | Borussia Dortmund | Ajax Amsterdam | Group C | 1-3 | 5 - 7 points |