| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 01/11/22 17:45 | FC Porto | Atletico Madrid | Group B | 2-1 |
| 01/11/22 17:45 | Bayer 04 Leverkusen | Club Brugge | Group B | 0-0 |
| 01/11/22 20:00 | Liverpool FC | SSC Napoli | Group A | 2-0 |
| 01/11/22 20:00 | Glasgow Rangers | Ajax Amsterdam | Group A | 1-3 |
| 01/11/22 20:00 | Viktoria Plzen | FC Barcelona | Group C | 2-4 |
| 01/11/22 20:00 | FC Bayern Munich | Inter Milan | Group C | 2-0 |
| 01/11/22 20:00 | Olympique Marseille | Tottenham Hotspur | Group D | 1-2 |
| 01/11/22 20:00 | Sporting Lisbon | Eintracht Frankfurt | Group D | 1-2 |
| 02/11/22 17:45 | Real Madrid | Celtic Glasgow | Group F | 5-1 |
| 02/11/22 17:45 | Schachtjor Donezk | RB Leipzig | Group F | 0-4 |
| 02/11/22 20:00 | Manchester City | FC Sevilla | Group G | 3-1 |
| 02/11/22 20:00 | FC Copenhagen | Borussia Dortmund | Group G | 1-1 |
| 02/11/22 20:00 | Maccabi Haifa | Benfica Lisbon | Group H | 1-6 |
| 02/11/22 20:00 | Chelsea FC | Dinamo Zagreb | Group E | 2-1 |
| 02/11/22 20:00 | Juventus Turin | Paris St. Germain | Group H | 1-2 |
| 02/11/22 20:00 | AC Milan | FC Red Bull Salzburg | Group E | 4-0 |