| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 25/10/22 17:45 | FC Sevilla | FC Copenhagen | Group G | 3-0 |
| 25/10/22 17:45 | FC Red Bull Salzburg | Chelsea FC | Group E | 1-2 |
| 25/10/22 20:00 | Celtic Glasgow | Schachtjor Donezk | Group F | 1-1 |
| 25/10/22 20:00 | RB Leipzig | Real Madrid | Group F | 3-2 |
| 25/10/22 20:00 | Borussia Dortmund | Manchester City | Group G | 0-0 |
| 25/10/22 20:00 | Paris St. Germain | Maccabi Haifa | Group H | 7-2 |
| 25/10/22 20:00 | Benfica Lisbon | Juventus Turin | Group H | 4-3 |
| 25/10/22 20:00 | Dinamo Zagreb | AC Milan | Group E | 0-4 |
| 26/10/22 17:45 | Club Brugge | FC Porto | Group B | 0-4 |
| 26/10/22 17:45 | Inter Milan | Viktoria Plzen | Group C | 4-0 |
| 26/10/22 20:00 | Ajax Amsterdam | Liverpool FC | Group A | 0-3 |
| 26/10/22 20:00 | SSC Napoli | Glasgow Rangers | Group A | 3-0 |
| 26/10/22 20:00 | Atletico Madrid | Bayer 04 Leverkusen | Group B | 2-2 |
| 26/10/22 20:00 | FC Barcelona | FC Bayern Munich | Group C | 0-3 |
| 26/10/22 20:00 | Eintracht Frankfurt | Olympique Marseille | Group D | 2-1 |
| 26/10/22 20:00 | Tottenham Hotspur | Sporting Lisbon | Group D | 1-1 |