| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 11/10/22 17:45 | FC Copenhagen | Manchester City | Group G | 0-0 |
| 11/10/22 17:45 | Maccabi Haifa | Juventus Turin | Group H | 2-0 |
| 11/10/22 20:00 | Schachtjor Donezk | Real Madrid | Group F | 1-1 |
| 11/10/22 20:00 | Celtic Glasgow | RB Leipzig | Group F | 0-2 |
| 11/10/22 20:00 | Borussia Dortmund | FC Sevilla | Group G | 1-1 |
| 11/10/22 20:00 | Dinamo Zagreb | FC Red Bull Salzburg | Group E | 1-1 |
| 11/10/22 20:00 | Paris St. Germain | Benfica Lisbon | Group H | 1-1 |
| 11/10/22 20:00 | AC Milan | Chelsea FC | Group E | 0-2 |
| 12/10/22 17:45 | SSC Napoli | Ajax Amsterdam | Group A | 4-2 |
| 12/10/22 17:45 | Atletico Madrid | Club Brugge | Group B | 0-0 |
| 12/10/22 20:00 | Bayer 04 Leverkusen | FC Porto | Group B | 0-3 |
| 12/10/22 20:00 | Glasgow Rangers | Liverpool FC | Group A | 1-7 |
| 12/10/22 20:00 | Viktoria Plzen | FC Bayern Munich | Group C | 2-4 |
| 12/10/22 20:00 | FC Barcelona | Inter Milan | Group C | 3-3 |
| 12/10/22 20:00 | Tottenham Hotspur | Eintracht Frankfurt | Group D | 3-2 |
| 12/10/22 20:00 | Sporting Lisbon | Olympique Marseille | Group D | 0-2 |