| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 13/09/22 17:45 | Viktoria Plzen | Inter Milan | Group C | 0-2 |
| 13/09/22 17:45 | Sporting Lisbon | Tottenham Hotspur | Group D | 2-0 |
| 13/09/22 20:00 | Liverpool FC | Ajax Amsterdam | Group A | 2-1 |
| 13/09/22 20:00 | Bayer 04 Leverkusen | Atletico Madrid | Group B | 2-0 |
| 13/09/22 20:00 | FC Porto | Club Brugge | Group B | 0-4 |
| 13/09/22 20:00 | FC Bayern Munich | FC Barcelona | Group C | 2-0 |
| 13/09/22 20:00 | Olympique Marseille | Eintracht Frankfurt | Group D | 0-1 |
| 14/09/22 17:45 | Schachtjor Donezk | Celtic Glasgow | Group F | 1-1 |
| 14/09/22 17:45 | AC Milan | Dinamo Zagreb | Group E | 3-1 |
| 14/09/22 20:00 | Glasgow Rangers | SSC Napoli | Group A | 0-3 |
| 14/09/22 20:00 | Manchester City | Borussia Dortmund | Group G | 2-1 |
| 14/09/22 20:00 | Real Madrid | RB Leipzig | Group F | 2-0 |
| 14/09/22 20:00 | FC Copenhagen | FC Sevilla | Group G | 0-0 |
| 14/09/22 20:00 | Maccabi Haifa | Paris St. Germain | Group H | 1-3 |
| 14/09/22 20:00 | Chelsea FC | FC Red Bull Salzburg | Group E | 1-1 |
| 14/09/22 20:00 | Juventus Turin | Benfica Lisbon | Group H | 1-2 |