Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 04/03/22 17:30 | 04/03/22 17:20 | SV Darmstadt 98 | 1. FC Heidenheim 1846 | 3-2 | 2 - 4 points |
| 04/03/22 17:30 | 04/03/22 17:20 | Holstein Kiel | SC Paderborn 07 | 3-4 | 2 - 4 points |
| 05/03/22 12:30 | 05/03/22 12:20 | FC St. Pauli | Karlsruher SC | 3-1 | 2 - 4 points |
| 05/03/22 12:30 | 05/03/22 12:20 | SV Sandhausen | Hannover 96 | 3-1 | 2 - 4 points |
| 05/03/22 12:30 | 05/03/22 12:20 | FC Schalke 04 | FC Hansa Rostock | 3-4 | 2 - 4 points |
| 05/03/22 19:30 | 05/03/22 19:20 | 1. FC Nürnberg | Hamburger SV | 2-1 | 2 - 4 points |
| 06/03/22 12:30 | 06/03/22 12:20 | Erzgebirge Aue | Jahn Regensburg | 1-0 | 2 - 4 points |
| 06/03/22 12:30 | 06/03/22 12:20 | Werder Bremen | Dynamo Dresden | 2-1 | 2 - 4 points |
| 06/03/22 12:30 | 06/03/22 12:20 | Fortuna Düsseldorf | FC Ingolstadt | 3-0 | 2 - 4 points |